Iranian Researchers Produce Engineered Neurons for Neurological Diseases’ Treatment

Sunday, October 14, 2018 - 15:55

Researchers of Islamic Azad University, Science and Research branch, could produce engineered neurons to promote neuronal cells’ functions and help to improve neurological and spinal cord diseases.

According to an ISCA report, the researcher, Parvin Pourmasoumi stated that in severe injuries that some parts of the peripheral and central nerves destroyed and the body is not able to recover them, extracting an effective nerve cell from stem cells is required.

As she explained, injecting stem cells into the target place is the common treatment, which is used in treating many diseases, including Parkinson's, Alzheimer's and spinal cord injuries but a desirable result is not achieved most of the time and the treatment is not fully done.

Pourmasoumi noted that in this research, the physiological conditions of a nerve cell has been improved in order to create the most similar one. 10 micrometers’ dimensions micro-groove, at a depth of 4 micrometers, with a stiffness of 2.5 Megapascal and retinoic acid growth factor, were used to create nerve-like cells in this research.

The result of the research, led by Dr. Azadeh Asefnejad and Dr. Mohammad Mehdikhani, showed that besides being sensitive to the dynamic mechanical stimuli, cells also quickly respond to the static mechanical environment around themselves.


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