TUOMS & Monash University Develop Macrophage Repolarization Using Emu Oil-Based Electrospun Nanofibers

Saturday, October 21, 2017 - 12:25

Researchers of Tabriz University of Medical Sciences (TUOMS) in cooperation with Monash University of Australia have developed Macrophage repolarization using emu oil-based electrospun nanofibers: possible application in regenerative medicine.

According to an ISCA report, the aim of this study was to evaluate the efficiency of electrospun nanofibrous scaffolds containing natural substances with anti-inflammatory properties such as Emu oil (EO) to control inflammation and re-polarization of macrophages toward M2 anti-inflammatory phonotype.

In this regard, Dr. Younes Pilehvar-Soltanahmadi, one of the researchers and faculty of advanced medical sciences of TUOMS, explained that electrospun nanofibrous scaffolds are becoming very important due to their wound dressing application or as the cell carriers to replace damaged skin tissue, therefore, various materials and compounds including collagen, PLGA and etc. are being used in creating this scaffold.

As he said, emu oil is made up of 70 percent essential fatty acids, a combination of omega-9, 6 and 3s. These properties give it its ability to reduce inflammation, relieve muscle and joint pain, moisturize the skin, and treat skin conditions. It also contains antioxidants and vitamins, such as vitamins E and A, so it was used as an animal extract in this project.

To reach to the purpose, bead free and smooth EO-blended PCL/PEG electrospun nanofibrous mats were successfully fabricated and characterized using FE-SEM, FTIR, and Universal Testing Machine. GC/MS findings of pure EO revealed the fatty acids composition. MTT results showed that macrophage viability on EO-PCL/PEG nanofibres was higher than on PCL/PEG nanofibres and control (p ≤ .05).

Additionally, the presence of EO into nanofibres was found to influence on macrophage morphologies, using FE-SEM. qPCR results showed a reduction in iNOS-2 and an increase in Arg-1 levels of macrophages seeded on EO-PCL/PEG nanofibres, indicating the successfully polarization of the macrophages to M2 phenotype.

The change in macrophage phenotype on EO-based nanofibres could suppress the inflammation in LPS/IFN-γ stimulated macrophages as evidenced by a major reduction in pro-inflammatory cytokine levels TNF-α, IL-1β, and IL-6. Conclusively, the results demonstrated that EO-based nanofibres efficiently modulated RAW264.7 macrophage polarity toward an anti-inflammatory M2 phenotype.

The research was carried out by School of Advanced Medical Sciences, Stem Cell Research Center (SCRC) of Tabriz University of Medical Sciences in cooperation with Australia Institute of Regenerative Medicine, affiliated with Monash University, and the results have been published in Experimental Cell Research journal.

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