S & R IAU Faculty Member Makes Temporary Skin Substitutes

Monday, October 23, 2017 - 13:22

A scientific project of faculty member of Science and Research Islamic Azad University has been honored in the International Conference on Nanofibers 2017 (ICNF 2017), held at Tehran University of Medical Sciences, on October 2017.

According to an ISCA report, Adeleh Gholipour-Kanani explained that the project “Tissue engineered poly (caprolactone)-chitosan-poly (vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing” aims at creating temporary skin substitutes through using Nanofiber coatings based on Chitosan-Poly-Caproklacton to achieve an efficient coating in healing various skin scars.

In this regard, She gave an explanation that Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly (Ε-caprolactone) (PCL)-chitosan (Cs)-poly (vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA.

The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of a cellular and with mesenchymal stem cells. They were applied on burn (n = 12) and excisional cutting (n = 12) wounds on dorsum skin of rats.

Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell-seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell-seeded scaffolds followed by a cellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing.

She noted that Electrospun nanofibrous scaffolds offer numerous advantages in comparison with other tissue engineered scaffolds because of their innate properties, that is high surface area and micro-porous structure which mimic the nanofibrils structure of native extracellular matrix (ECM).

These properties afford quickly start signalling pathway and attract fibroblasts to the derma layer, which can excrete important ECM components, such as collagen and several cytokines (e.g. growth factors and angiogenic factors) to repair the damaged tissue.

The research was carried out by Adeleh Gholipour-Kanani in cooperation with Hajir Bahrami, Amirkabir University of Technology, department of Textile Engineering.

The international conference on nanofibers 2017 (ICNF 2017) was held at Tehran University of Medical Sciences, on October 2017. Participants from the top international academic, government and private industry labs of different disciplines participate in ICNF 2017 to identify new technology trends, development tools, product opportunities, R&D collaborations, and commercialization partners.

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