Dr. Velayati Most Recent Scientific Article

Discovering the Totally Drug Resistant Tuberculosis

Monday, December 11, 2017 - 09:56

The head of IAU board of directors and trustees, Dr. Ali Akbar Velayati in cooperation with Parissa Farnia and other colleagues in Respiratory Diseases Research Center of Masih Daneshvari Hospital have discovered the reason of drug resistant tuberculosis.

According to an ISCA report, the article “20th-century version of an old pathogen. Drug resistant Tuberculosis” was revealed in an official website of Atlas of Science affiliated to MIT University.

Based on the research, Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world.

Besides this the rapid evolution of Mycobacterium tuberculosis, from mono-drug-resistant to multiple drug-resistant [MDR-TB; isolates that are resistance to at least isoniazide (INH) and rifampicin (RIF)], extensively drug-resistant [XDR-TB; defined as MDR with additional resistance to both fluoroquinolones and at least one second –line injectable drug], and most recently extremely drug resistant (XXDR) or totally drug-resistant strains (TDR-TB), is threatening to make TB once again an untreatable disease if new therapeutic options do not soon become available.

Results show that “the combination of available drugs might not work-well for these deadly bacilli, but for the time –being we can strictly follow international policy on TB infection control in health-care facilities, congregate settings and households. And maybe we have to revise the transmission strategies when we our concern is XDR or TDR-TB bacilli.”

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