Researchers Develop Chitosan Hydrogel Intended for Cartilage Tissue Engineering

Wednesday, January 31, 2018 - 15:44

Researchers from Amirkabir University of Technology have created biocompatible hydrogel to rehabilitate damaged cartilage in patients with arthritis.

According to an ISCA report, the researcher of the project, Mana Kashi explained that electroactive scaffolds containing conductive polymers can promote tissue repair and regeneration. However, these polymers are non-degradable and cannot be removed from body.

As he said, to overcome this limitation of conductive polymers, researchers developed a novel injectable electroactive hydrogel containing pyrrole oligomers which possessed the unique properties of being both electrically conductive and biodegradable.

In this research, first, pyrrole oligomers were synthesized via chemical polymerization and were found to be amorphous with a non-globular morphology. Then, three different compositions of injectable chitosan/beta glycerophosphate hydrogels containing different concentrations of pyrrole oligomers were synthesized and characterized for chemical structure, morphology, conductivity, swelling ratio, In vitro biodegradation and gelation time.

An increase in oligopyrrole content resulted in decreased pore size, and increased gelation time, swelling ratio, conductivity and degradation time. Among all the hydrogel compositions, the sample with pyrrole oligomer: chitosan ratio of 0.1 (w/w) showed the most prominent biodegradability, biocompatibility, electro-activity, swelling ratio and pore size values and was chosen as the optimal electroactive hydrogel composition in this work.

The research was done by the cooperation of Dr. Fatollah Moztarzadeh, Dr. Hamid Mobasheri and Dr. Elahe Kosari in Amirkabir University of Technology.


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