S & R IAU Researcher Develops a Method to Treat Abnormalities Associated with Retinal Diseases

Wednesday, June 13, 2018 - 14:41

A researcher from Islamic Azad University, Science and Research branch has designed and developed a carrier with EGFP as a reporter, under the control of RAX regulatory sequence.

According to an ISCA report, the researcher Atefeh Atefi explained that optical receptor cell destruction especially in retinal neurons will lead to the blindness, but today, stem cell technology and cell therapy are being applied for replacement of lost cells.

She spoke of “Gene Cloning” technique in her research and noted that gene cloning involves separation of specific gene or DNA fragments from a donor cell, attaching it to small carrier molecule called vector and then replicating this recombinant vector into a host cell.

Isolation of donor DNA fragment or gene, selection of suitable vector, incorporation of donor DNA fragment into the vector, transformation of recombinant vector into a suitable host cell and isolation of recombinant host cell are steps involved in gene cloning.

When DNA is extracted from an organism, all of its genes are extracted at one time. This DNA, which contains thousands of different genes. The genetic engineer must find the one specific gene that encodes the specific protein of interest.

Atefi added that whenever we may become sure that the Promoter Sequence, which is related to the specific gene of these cells, has Regulatory Potential, it can be concluded that the target cell, is the retinal precursor cell.

The research has been carried out by Atefeh Atefi, student of biocellular-molecular of Science and Research IAU.


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