Iranian Researchers Produce Nanocapsules Containing Antioxidants From Common Kilka

Monday, July 2, 2018 - 16:05

Researchers from Tarbiat Modares University have produced bioactive peptides using marine resources that are without the unpleasant taste of peptides derived from fish.

According to an ISCA report, Fish-purified antioxidant peptide (AOP)-loaded chitosan nanoparticles (CSNPs) were synthesized based on the ionotropic gelation between CS and sodium tripolyphosphate (TPP).

Based on the research carried out by Tarbiat Modares University researchers, Transmission electron microscopy (TEM) images also revealed roughly uniform spherical-shaped nanoparticles with diameter of< 100 nm. Molecular interactions among the components of the NPs and peptides were confirmed by FT-IR spectroscopy.

Thermo-gravimetric analysis (TGA) results showed the improved thermal stability of the AOP-loaded CSNPs compared with free peptides. The maximum peptide encapsulation efficiency was determined to be 71.16% and the in vitro release of peptides from CSNPs was in a controllable manner.

Furthermore, assessing the free radical scavenging ability of the peptide-encapsulated NPs and the reducing power assay, confirmed the efficacy of such nanosystem in retaining the antioxidant activity of fish-derived peptides.

The study done by Seyed Fakhreddin Hosseinia, Mohammad Reza Soleimania and MaryamNikkhah and the result was published in Elsevier, International Journal of Biological Macromolecules.


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