S & R IAU Researchers Create Drug Carrier Using Olibanum

Tuesday, July 10, 2018 - 09:40

Researchers from Science and Research Islamic Azad University have synthesized gelatin scaffolds, chitosan and microspheres as drug carriers through using Olibanum.

According to an ISCA report, Parastoo Namdarian explained that in recent years, the strategy of using microspheres as drug carrier system has been considered very much and due to the increasing of life expectancy, the importance of repairing and replacing defective tissues, especially bone tissue has become noticeable.

Based on the research, the use of natural polymers for pharmaceutical applications is very attractive. Given that various polymer materials are available for making microspheres, there is an active research to develop new, safe and effective release for microspheres.

Olibanum is used as a drug carrier in this study. Also dexamethasone (DEX) is one of the commonly bioactive molecules used in bone tissue engineering.

In this research, the purification and characterization of olibanum were first studied by FTIR, XRD, pH determination and MTT test. Due to its non-toxicity, biocompatibility, availability and biodegradability, this material can be a good choice as a natural polymer.

Then the microspheres were synthesized with single emulsion method and studied by SEM and FTIR. The morphology and structure of the microspheres revealed that they are spherical and separate, which have rough and porous surface. Also the release mechanism of drug from olibanum microspheres was determined in accordance with the different kinetic drug release models.

Investigating the drugs release behavior and degradation rate of microspheres revealed that they were suitable for dexamethasone-controlled release and can be used well in tissue engineering scaffolds.

The research, “Preparation, Characterization and Drug Delivery Behavior of Dexamethasone-Loaded Olibanum Microsphere” was carried out by Parastoo Namdarian, Ali Zamanian, Azadeh Asefnejad and Maryam Saeidifar in IAU Science and Research branch.

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