Researchers Targeting Metabolism that Can Defeat Cancer Stem Cells

Saturday, July 28, 2018 - 14:33

Researchers at the University of Michigan Rogel Cancer Center have found that cancer stem cells exist in more than one state and are very plastic, meaning they can change form, sliding back and forth between a dormant state and a rapidly growing state.

Based on a new research, carried out at the University of Michigan Rogel Cancer Center, cancer stem cells exist in more than one state and are very plastic, meaning they can change form, sliding back and forth between a dormant state and a rapidly growing state. This plasticity is responsible for cancer’s two key characteristics: multiplying and spreading, Michigan Medicine University of Michigan reports.

“When we use targeted therapies, they often only work for a certain period of time, and then the cancer becomes resistant. A lot of that resistance is from the cancer stem cells. They change form to evade the targeted therapy,” says Wicha, Madeline and Sidney Forbes professor of oncology and director of the Forbes Institute for Cancer Discovery at the Rogel Cancer Center.

It turns out the cell metabolism controls this change, suggesting a possible way in to attack the stem cells. Cells get energy through mitochondria, which depends on oxygen, and through sugar, or glucose. Cancer stem cells pull energy both ways. In the dormant state, the cells use glucose; in the proliferative state, they depend on oxygen.

So researchers attacked the metabolism in both ways. They used a drug currently used to treat arthritis that’s known to block mitochondria, and they manipulated glucose to block that path. They tested this in mice with breast cancer and found they could knock out the stem cells. Results are published in Cell Metabolism.

“Rather than just try to use toxic chemicals to kill a cell, we use the metabolism of the cell itself to kill the cancer,” Wicha says.

Researchers are also understanding that the immune system is regulated by metabolism, suggesting the possibility of combining anti-stem cell therapies with immunotherapies.

Related News

Applying the Potential of Menstrual Blood-Derived Stem Cells in Differentiation to Epidermal Lineage

1397/5/21 11:24

New Research May Expand Stem Cells Available For Transplants

1397/5/13 12:15

Najafabad IAU Researchers Produce Nanocomposite to Eradicate Cancerous Bone Cells

1397/5/7 12:33

Researchers Create Magnetized Wire to Detect Cancer

1397/4/26 16:03

CNBP Scientists Developed a New Targeted Treatment for Cancer

1397/4/26 12:50

Scientists Discover Potential 'Achilles Heel' in Brain Cancer

1397/4/10 16:34

Researchers Discover Gene That Triggers Aging Symptoms

1397/4/6 15:50

Engineers Make World’s Smallest ‘Computer’

1397/4/3 12:53

Researchers Camouflage a Cancer-Killing Drug Using Cells From the Tumor Itself

1397/3/30 13:39

Researchers Develop a New Kind of Vaccine Based on Spider Silk

1397/3/27 15:24

AEOI, IUMS to Set Up Cancer Treatment Center

1397/3/21 10:18

New Blood Test Could Find 10 Different Types of Cancer at an Early Stage

1397/3/13 09:25

Researchers Make Quantum Dots Out Of Tea Leaves Lay Waste to Lung Cancer Cells

1397/3/5 08:26

Scientists Discover Likely Cause of Childhood Leukemia

1397/3/2 11:58

MIT Biologists Discover Fasting Can Boost Stem Cells' Regenerative Capacity

1397/2/19 13:27

Researchers Discover New Organ That May Help Explain How Cancer Spreads

1397/1/8 13:21

Iran to Develop Palliative Care Centers for Cancer Patients

1396/12/2 11:19

Nanorobots Can Starve and Shrink Cancerous Tumors

1396/11/24 16:18

Najafabad IAU Researchers to Breed Scorpion, Milk Venom for Medical Purposes

1396/11/7 10:39

A New Blood Test Could Detect Signs of 8 Kinds of Cancer

1396/10/30 11:01

Researchers Develop Innovative Approach for the Remote Control of Gene & Cell Activations

1396/10/27 10:13

Iranian Researcher Helps to Create a Diagnostic "Lab on a Chip" For Just a Penny

1396/9/18 10:30

This Biohybrid Robot Can Swim Through the Body

1396/9/4 16:15

Opinions


Popular News

Latest News