Najafabad IAU Researchers Produce Nanocomposite to Eradicate Cancerous Bone Cells

Sunday, July 29, 2018 - 12:33

Researcher of Najafabad Islamic Azad University in cooperation with Isfahan University of Medical Sciences have succeeded in producing a nanocomposite which are able to solve essential problems after implantation including inflammation and osteomyelitis and also bone cancerous tissues through hyperthermia treatment.

According to an ISCA report, Osteosarcoma (also called osteogenic sarcoma) is the most common type of cancer that starts in the bones. The cancer cells in these tumors look like early forms of bone cells that normally help make new bone tissue, but the bone tissue in an osteosarcoma is not as strong as that of normal bones.

Hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 113°F). Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia may shrink tumors.

The aim of this study, done by Ashkan Bigham, MS student of Najafabad IAU and Mohammad Rafienia, faculty member of Isfahan University of Medical Sciences, was to design and develop a new multifunctional composite containing a magnetic zinc ferrite as a core, and nanoporous zinc silicate as a shell via a two-step synthesis strategy to meet all above targets simultaneously.

ZnFe2O4 particles are synthesized via solvothermal method and then coated through surfactant-assisted sol-gel method to obtain zinc silicate-ZnFe2O4 composite using cetyltrimethylammoniumbromide (CTAB) as a surfactant.

The XRD results show that the composite has a glass-ceramic structure. The FESEM micrographs indicate the increase in the size of ZnFe2O4 particles because of zinc silicate formation around them. The vibrating sample magnetometer (VSM) results reveal that the formation of zinc silicate over ZnFe2O4 particles caused the magnetization saturation (Ms) to be reduced from 43 to 30 emu g−1.

The antibacterial activity of the composite is evaluated against S. aureus and E. coli bacteria. Heat generation capability of the composite is assessed in vitro and results show that the composite reached the saturation temperature of 45 °C up to 510 s with 200 Oe magnetic field and constant 200 kHz frequency.

Potential application of the composite as a controlled release system is assessed in vitro up to 240 h. The cell compatibility of the composite with different concentrations is assessed using osteoblast-like cells (MG63) up to 48 h.

The article was published in Ceramics International Journal, Volume 44, Issue 10, July 2018, Pages 11798-11806.

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