Researchers of Avicenna Research Institute

Applying the Potential of Menstrual Blood-Derived Stem Cells in Differentiation to Epidermal Lineage

Sunday, August 12, 2018 - 11:24

The head of Avicenna Research Institute has announced on treating skin damages using menstrual blood-derived stem cells.

Dr. Mohammad Reza Sadeghi stated that menstrual blood-derived stem cells (MenSCs) are a novel source of stem cells that can be easily isolated non-invasively. These mesenchymal-like stem cells have high rate of proliferation and possess multi lineage differentiation potency, ISNA reported in his Persian version website.

Stem cells as self-renewing cells proliferating without differentiation, and under defined conditions can differentiate into various cell types. The stem cells can be categorized into two major groups of embryonic stem cells (ESCs) and adult stem cells (ASCs).

Based on the research, the newly defined adult stem cells are menstrual blood-derived stem cells (MenSCs), giving rise to hopes in clinical application of these cells. They are mesenchymal-like stem cells that can be harvested from human menstrual blood shedding of endometrium monthly.

Molecular profile assay shows that MenSCs express some pluripotency markers including Oct-4, SSEA-4, nanog, and c-kit and also some mesenchymal stem cells specific markers such as CD9, CD29, CD44. So MenSCs are a good source of stem cells in research for differentiation into different cells and use in regenerative medicine.

Therefore, MenSCs would be a valuable choice in cell-based therapies and we can consider their potential in clinical trials especially repair of dermatological lesions. Skin regeneration and repair has become the main goal of dermatological treatments including wrinkles, photoaging, cutaneous deep wounds, and burns as they are still major concerns in dermocosmetics.

The isolated MenSCs were adhered to the plate and exhibited spindle-shaped morphology. Flow cytometric analysis revealed the expression of mesenchymal markers of CD10, CD29, CD73, and CD105 and lack of hematopoietic stem cells markers. An early success in derivation of epidermal lineage from MenSCs was visible.

The research has been carried out by Hossein Faramarzi, Larestan School of Medical Science, Davood Mehrabani, Shiraz University of Medical Science, Maryam Fard and Maryam Akhavan, Qazvin University of Medical Sciences, Sona Zare and Shabnam Bakhshalizadeh, Tehran University of Medical Sciences, Amir Manai, Shahid Beheshti University of Medical Sciences, Somaieh Kazemnejad, Avicenna Research Institute and Reza Shirazi, University of Medical Sciences.

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