Researchers Develop a System Allows Rapid Response to Heart Attacks without Surgical Intervention

Monday, August 13, 2018 - 10:04

Researchers of North Carolina State University and the University of North Carolina at Chapel Hill have developed a drug-delivery system that allows rapid response to heart attacks without surgical intervention.

According to the NC State University, in laboratory and animal testing, the system proved to be effective at dissolving clots, limiting long-term scarring to heart tissue and preserving more of the heart’s normal function.

“Our approach would allow health-care providers to begin treating heart attacks before a patient reaches a surgical suite, hopefully improving patient outcomes,” says Ashley Brown, corresponding author of a paper on the work and an assistant professor in the Joint Biomedical Engineering Program (BME) at NC State and UNC.

“And because we are able to target the blockage, we are able to use powerful drugs that may pose threats to other parts of the body; the targeting reduces the risk of unintended harms.”

Heart attacks, or myocardial infarctions, occur when a thrombus – or clot – blocks a blood vessel in the heart. In order to treat heart attacks, doctors often perform surgery to introduce a catheter to the blood vessel, allowing them to physically break up or remove the thrombus. But not all patients have quick access to surgical care.

And more damage can occur even after the blockage has been removed. That’s because the return of fresh blood to tissues that had been blocked off can cause damage of its own, called reperfusion injury. Reperfusion injury can cause scarring, stiffening cardiac tissue and limiting the heart’s normal functionality.

To address these problems, researchers have developed a solution that relies on porous nanogel spheres, about 250 nanometers in diameter, which target a thrombus and deliver a cocktail of two drugs: tPA and Y-27632.

“This is an important part of our findings, because tPA and Y-27632 can both pose risks if they begin acting on parts of the body outside of the targeted area,” Brown says. “For example, tPA can cause bleeding and Y-27632 can affect many tissues where cell contraction is needed for normal function.”

One other benefit of the targeted nanogels is that, due to their small size, they can target even those blood vessels that are too small to reach using catheters.

The researchers also note that this is a preclinical study. Next steps for the work include further evaluating the safety of the nanogels and testing in larger animal models.

The paper, “Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic,” is published in the journal ACS Nano. Co-lead authors are Emily Mihalko, a Ph.D. student in the joint BME program, and Ke Huang, a Ph.D. student at NC State. The paper was co-authored by Ke Cheng, a professor of biomolecular sciences at NC State and a professor in the joint BME program, and by Erin Sproul, a former postdoctoral researcher in the joint BME program. All of the study authors are members of the Functional Tissue Engineering group of the Comparative Medicine Institute (CMI) at NC State, which facilitated this interdisciplinary collaboration.


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