S & R IAU Researcher Prevents Colorectal Cancer through Ginger Extract

Tuesday, September 25, 2018 - 15:49

Science and Research IAU researcher has investigated the effects of ginger extract on genes involved in colon cancer to create a link between agricultural and medical biotechnology.

According to an ISCA report, Shahrzad Pedramjam explained that the effect of ginger metabolites on PTEN and BCL2, two genes involving in colon cancer, was studied in this research.

Based on the previous researches, ginger acts as an anti-inflammatory and blocks both cyclooxygenase (COX) and lipoxygenase (LOX) enzymes that produce procancer eicosanoids. It also has antitumor action independent of these anti-inflammatory effects. An extract of “ginger, can enhance the anticancer effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

Based on the results, ginger extract has a significant effect on BCL2 genes, as regulators of cancer cell invasion and metastasis, as well as on PTEN gene, identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.

The research has been done by Shahrzad Pedramjam and advised by Dr. Asa Ebrahimi and Dr. Mehdi Rahaei in Science and Research IAU, Faculty of Agricultural Sciences and Food Industry.

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