Iranian Scientists Biosynthesize Nanoparticles Using Principles of Green Chemistry

Sunday, October 7, 2018 - 14:45

A team of researchers from Zabol University of Medical Science has biosynthesized cerium oxide nanoparticles (CeO2-NPs) using the aqueous extract of aerial parts of Prosopis farcta which can have the potential of being utilized in various fields of medicine, such as drug delivery.

According to an ISCA report, today, using the principles of green chemistry, a special place has been found in the production of nanoparticles and for this purpose; researchers have employed diverse biological systems.

Plants and crops have been given an exceptional attention because they are considered as cheap and renewable resources for nanomaterials production.

The researcher, Mina Sarani explained that Cerium oxide nanoparticles (CeO2-NPs) have been biosynthesized using the aqueous extract of aerial parts of Prosopis farcta. This plant contains phenolic compounds that function as reducing and capping agents.

Based on the study, Biosynthesized particles have been characterized through the use of UV–, PXRD, TEM, FESEM, EDX, Ramanand FTIR analysis. The UV–vis spectrum clearly showed absorption peak at 317 nm, which indicated the for-mation of spherical CeO 2-NPs.

It displayed in the FESEM and TEM images that the biosynthesized particles are uniformly and spherically shaped with a size of about 30 nm, while the EDX has clearly shown that only the elements Ce and O are present in the biosynthesized sample. Moreover, the Raman spectrum of synthesizednanoparticles has displayed a Ce-O stretching band at a measurement of 459 cm−1.

The cytotoxic activity of biosynthesized nanoparticles against the HT-29 cancer cell line was studied using the MTT assay. All the concentrations of CeO2-NPs (0–800 μg/ml) showed non-toxic effects and thus, it can be suggested that these nanoparticles have the potential of being utilized in various fields of medicine, such as drug delivery.

The results of the research, carried out by Mina Sarani and Abdolhossein Miri, faculty member of Zabol University of Medical Science, has been published in Ceramics International scientific journal.

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