S & R IAU Researcher Presents Skin Anti-Aging Strategy

Saturday, November 17, 2018 - 12:03

A researcher from Islamic Azad University has presented a process to boost the effects and durability of acid hyaluronic gels in skin care.

According to an ISCA report, skin aging is a complex biological process influenced by a combination of endogenous or intrinsic and exogenous or extrinsic factors. Because of the fact that skin health and beauty is considered one of the principal factors representing overall “well-being” and the perception of “health” in humans, several anti-aging strategies have been developed so far.

Aging is as much about the physical processes of repair and regeneration, and their slow-motion failure, as it is the passage of time. Hyaluronic acid is a naturally-occurring substance in skin known for its stunning capacity to attract and hold onto 1000x its weight in moisture. It works overtime by replenishing skin to enhance a healthy, supple look and feel.

Hyaluronic acid is also a humectant, which is a category of skin care ingredients that are hygroscopic, meaning they draw moisture from their surroundings. Humectants are often found in water-based moisturizers, serums, and other leave-on skin care products because of their ability to help boost hydration for all skin types.

Based on the research, among the variety of techniques to control aging, injectable hyaluronic acid dermal fillers have been found lots of attraction. However, the weakness in cell attachment and low durability of hyaluronic acid hydrogels caused problems in regeneration and rejuvenation. In this regard, Farnaz Ghorbani carried out some researches and presented a process to boost the effects and durability of acid hyaluronic gels in skin care, ANA reports.

In this study, pullulan, hydroxyapatite particles, and GPTMS were added to the solution in order to the improvement of cell-filler interactions and durability, respectively. Due to the higher biocompatibility of biomimetic hydroxyapatite, it has been selected in this research through mineralization of hydroxyapatite on the bioactive substrate.

The substrate was polydopamine nanospheres and gelatin-siloxane microsphere. It should be noted that fabrication of bioactive spheres had lots of challenges such as water to alcohol ratio, pH regulators, and monomer addition technique for polydopamine nanospheres and types of the oil phase and washing procedure for gelatin microspheres.

According to the results, the produced particles in tris-contained isopropanol with the drop-wise addition of monomer leading uniform and homogeneous formation of polydopamine nanospheres (441±24 nm). Moreover, usage of olive oil and washing with acetone under ultrasonication ended to the fabrication of monosize and homogeneous gelatin microspheres (40-70 μm).

Beside the evaluation of SBF on biomineralization of hydroxyapatite, the effect of modified SBF in presence and absence of microwave irradiation was investigated. Results indicated the uniform sedimentation of carbonated nano-hydroxyapatite in the lower time.

In order to fabrication of composite hydrogels, the study was continued on gelatin microspheres owing to homogeneous dispersion of particles in hydrogel. Results demonstrated the reduction in viscosity (3000 to 600 Pa.s) and modulus (320 to 100 Pa) and improvement of cell attachment by addition of pullulan.

In contrast, the hydroxyapatite microspheres increase stability of rheological features in different frequencies and shear rates. Decreasing biodegradation rate and providing desirable site for cell anchorage are the other properties obtained by these particles. But According to the results, the hyaluronic acid-pullulan-biomimetic hydroxyapatite on gelatin-siloxane microspheres showed initial physicochemical and mechanical properties for further in-vitro and in-vivo analysis.

The results of the study has been published in Materials Science and Engineering C, Applied Polymer Sciences and E-polymers as well.

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