Semnan University Researchers Synthesize Nanostructures Healing Bone Defects and Fractures

Sunday, August 4, 2019 - 15:40

Researchers of Semnan University in cooperation with a tech company ,based in Semnan University Science and Technology Park, have succeeded in synthesizing porous nanostructures that can help healing bone defects and fractures through simulating bone tissues.

According to an ISCA report, the research ‘Porous fluorhydroxyapatite-magnesium-gelatin novel composite scaffold based on freeze-drying mechanism for bone tissue engineering application’ was carried out by Mohammad Soltani, Mardali Yousefpour and Zahra Taherian, faculty of Materials and Metallurgical Engineering, Semnan University.

Based on the research, published in Materials Letters, porous fluorhydroxyapatite (FHA)/magnesium (Mg)/gelatin (Gel) scaffolds with various amounts of FHA (30, 40, 50wt%) were fabricated through freeze-drying procedure. Microscopic investigations indicated a porous microstructure with pores diameter in the range of 150–250 μm, which is acceptable for osteoblastic cells to proliferate.

Additionally, successful replacement of fluorine ion in the structure of hydroxyapatite and suitable incorporation of compounds in the scaffolds were verified. Hence increasing the amount of fluohydroxyapatite in the structure of scaffolds has also played a significant role in improving mechanical properties and promoting biological aspects.

The results showed that using Mg, Gel and FHA as a fuctional compound, due to the development of non-toxic aspects and mechanical properties, can lead to a massive evolution in bone tissue engineering applications.


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