Shahrekord IAU Faculty Member Develops Anti-Gastric Cancer Drug

Tuesday, November 12, 2019 - 13:16

Farhang Tirgir, faculty member of Shahrekord Islamic Azad University, have succeeded in designing, synthesizing and developing an effective anti-gastric cancer drug.

In his interview with ISCA News Agency, Farhang Tirgir stated that cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer.

He continued that despite researchers’ efforts to find effective and practical solutions for cancer treatment, finding more effective treatments is still considering as a serious problem.

Based on the research which its results have been published in Journal of Molecular Liquids, over the past decades, anti-cancer drugs consist of cytotoxic drugs, have been interested and developed.

“Despite the great advances in chemotherapy, there is still no certain medical treatment for cancer. During this investigation, a novel 2,5-diketopiperazine derivative 3(R),6(S)-bis (4-hydroxy phenyl)-piperazine-2,5-dione: (BHPPD) was designed, synthesized, and evaluated.

“The effects on intestinal protease consist of conformation, activity, and cytotoxic effect on cancer cell lines by the various methods were assessed. The binding interaction between BHPPD with α-Chymotrypsin (α-Chy) has been described utilizing many spectroscopic and computational approaches.

“Intrinsic fluorescence analyses exhibited static quenching as the primary quenching mod in α-Chy–BHPPD interaction, which is further confirmed by UV–vis analyses. Likewise, binding and thermodynamic constants are estimated from temperature dependent fluorescence results.

“Furthermore, structural alterations of the enzyme upon binding with BHPPD were presented by circular dichroism (CD) analyses. The Molecular docking assessment presented the specific binding microenvironment of BHPPD in α-Chy. Besides with this research, molecular dynamics Simulation is performed to estimate the stability of α-Chy, α-Chy–BHPPD system.

“These results showed the vigorous binding affinity of the drug with intestinal protease. MTT analysis of BHPPD represented high cytotoxic effect against AGS cell line compared to normal cell line. Quantitative analysis shows that BHPPD treatment significantly increased the expression of caspase3, 9, and 8 genes and decreased GR expression in AGS cell line. Our team hopes that the results of this research will be useful for medical science and pharmacy.”

The research was carried out by Farhang Tirgir in cooperation with Sadegh Farhadian, Behzad Shareghi, Somayeh Reiisi, Neda Gholamian Dehkordi, Lida Momeni from Payame Noor University and Ehsan Heidari Soureshjani from Shahrekord IAU Young Researcher and Elites Club.


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