Iranian Researchers Design Microfluidic Platform for CTC Isolation and Enquiry

Saturday, December 14, 2019 - 12:12

Researchers from Sharif University of Technology have designed microfluidic platform for CTC isolation and enquiry for the first time in the country.

According to an ISCA report, a research team, led by Dr. Amir Shamloo, could simulate a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells.

Based on the research, “this separation unit is integrated with a mixer subunit. The mixer is envisioned for mixing the CTC enriched stream with lysis buffer to extract the biological material of the cell.

“Some modification was proposed on mixing geometry improving the efficacy of the functional unit. A valuation of engaged forces was made and some forces were neglected due to their order of magnitude.

“The position of the magnet was also optimized by doing parametric study. For the mixer unit, the effect of applied voltage and frequency on mixing index was studied to find the optimal voltage and frequency which provides better mixing.

“Above-mentioned studies were done on isolated units and the effect of each functional unit on the other is not studied. As the final step, an integrated microfluidic platform composed of both functional subunits was simulated simultaneously.

“To ensure the independence of results from the grid, grid studies were also performed. The studies carried out on the construct reveal its potential for diagnostic application.”


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