Researchers Discover Secrets of Cell Division

Wednesday, January 15, 2020 - 15:47

Researchers at Princeton University have uncovered the vital role played by a protein that is elevated in over 25% of all cancers.

According to the phys.org, researchers recreated a key process involved in cell division in a test tube, uncovering the vital role played by a protein that is elevated in over 25% of all cancers.

Based on the research results, released in the journals eLife and Nature Communications, the findings are a key step toward recreating the entire cell division machinery and could lead to new therapies aimed at preventing the growth of cancer cells.

When cells divide, a spindle-like structure composed of thousands of filaments called microtubules attaches to chromosomes and pulls equal numbers of them into each newly forming cell.

Each microtubule is assembled from individual tubulin molecules and, because errors in chromosome segregation can lead to cancer, it is vital that they assemble into microtubules at the right time and place to form a functional spindle apparatus.

Branching microtubule nucleation, in which a new microtubule forms from the side of an existing one, is crucial to this process because it allows the cell to form large numbers of microtubules that all point toward chromosomes, enabling their capture by the spindle.

"To better understand the mechanism of branching microtubule nucleation, we set out to reconstitute the process outside of the cell using purified proteins," said Sabine Petry, assistant professor of molecular biology at Princeton.

"In addition, our reconstitution of branching microtubule nucleation is an important step toward reconstituting the entire spindle apparatus, as well as other cellular structures that depend on this microtubule assembly pathway," Petry said.

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کد خبر: 697148 0 0

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