Royan Institute Researchers to Use Stem Cell Therapy for PKD

Monday, January 20, 2020 - 12:39

Researchers of Royan Institute have succeeded to take a great step toward developing stem cell therapy for Polycystic Kidney Disease “PKD”.

According to an ISCA report, Polycystic Kidney Disease or “PKD” is a medical condition wherein numerous fluid-filled cysts are found to have grown in either or both kidneys.

As the research project executor Dr. Reza Moghadasali explained, a kind of medicine has been developed for this genetic disease treatment, also hoped for preparing the drug for the laboratory phases.

Based on the research released in Current stem cell research & therapy by Dr. Moghadasali, “renal disease is a major worldwide public health problem that affects one in ten people.

“Renal failure is caused by irreversible loss of the structural and functional units of kidney (nephrons) due to acute and chronic injuries. In humans, new nephrons (nephrogenesis) are generated until the 36th week of gestation and no new nephron develop after birth.

“However, in rodents, nephrogenesis persists until the immediate postnatal period. The postnatal mammalian kidney can partly repair their nephrons. The kidney uses intrarenal and extra-renal cell sources for maintenance and repair.

“Currently, it is believed that dedifferentiation of surviving tubular epithelial cells and presence of resident stem cells has important roles in kidney repair. Many studies have shown that stem cells obtained from extra-renal sites such as the bone marrow, adipose and skeletal muscle tissues, in addition to umbilical cord and amniotic fluid, have potential therapeutic benefits.”


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