Scientists Develop Roadmap for 3D Bioprinting

Saturday, February 15, 2020 - 11:02

Researchers and scientists from various universities, institutions and hospitals in the world have successfully created a roadmap for 3D bioprinting.

According to the 3D Printing Industry report, scientists detail the current state of bioprinting, in a paper released in Biofabrication, including recent advances of the technology in selected applications as well as the present developments and challenges. The paper also envisions how the technology can improve in the future, and details the research that went into creating the roadmap.

Each of the authors takes on different aspects of bioprinting technology to focus on within the study. Specifically, these topics range from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human-scale tissue structures, and from building cell/tissue/organ-on-a-chip to biomanufacturing of multicellular engineered living systems.

In the introduction of the paper Wei Sun, chair professor of the College of Engineering from Drexel University, in Philadelphia, and Tsinghua University in Beijing, China, explains the challenges that must be overcome in bioprinting in general.

The first section, “From cell expansion to 3D cell printing,” discusses the importance of cell expansion in the bioprinting process. It states that bioreactor-based cell-expansion systems need to be improved to increase the adoption of bioprinting in regenerative medicine and tissue engineering product markets. Bioreactor-based systems are able to expand cells much faster than traditional methods leveraging flat culture plate solutions.

Another topic covered is the bioprinting of stem cells. This is a field that maintains “great promise for biomedical research and applications, owing to their strong renewability as a cell source, and potential to differentiate and mature into many cell types in the human body,” according to the researchers.

The paper goes on to discuss the “Large-scale and efficient production of organoids or cell aggregates.” Organoids are useful in that they effectively mimic the physiological microstructures of in vivo tissue or organs. A significant obstruction to the large-scale production of organoids is the high production costs and difficulty associated with producing them.

“The bioprinting roadmap” is published in Biofabrication, and is written by a number of authors, including Binil Starly, professor of mechanical engineering at North Carolina State University; Jason Burdick, a bioengineer from the University of Pennsylvania; Gregor Skeldon, a life science medical writer at Maverex, in the UK; Wenmiao Shu, professor of biomedical engineering at the University of Strathclyde in Glasgow; Andrew Daly, an orthopedic surgeon at Emory University Hospital; Jürgen Groll, professor of functional materials in medicine and dentistry at the University of Würzburg in Germany; Dong-woo Cho, mechanical engineer at Pohang University of Science and Technology; Vladimir A. Mironov, chief scientific officer of 3D Bioprinting Solutions.

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