Iranian Researchers Could Diagnose Bladder Cancer 10 Years Earlier

Wednesday, February 19, 2020 - 10:14

Iranian researchers from Iran University of Medical Sciences in cooperation with international scientists have been succeeded in diagnosing bladder cancer 10 years earlier.

According to an ISCA report, early detection of cancer greatly increases the chances for successful treatment. There are two major components of early detection of cancer: education to promote early diagnosis and screening.

In this regard, researchers of Iran University of Medical Sciences worked on pre-clinical bladder cancer (BC) detection using urinary biomarkers which may provide a valuable opportunity for screening and management and released their findings in EBioMedicine.

Based on the research, researchers performed a nested case-control study within the population-based prospective Golestan Cohort Study (50,045 participants, followed up to 14 years) and assessed TERT promoter mutations in baseline urine samples from 38 asymptomatic individuals who subsequently developed primary BC and 152 matched controls using a Next-Generation Sequencing-based single-plex assay (UroMuTERT) and droplet digital PCR assays.

“Results were obtained for 30 cases and 101 controls. TERT promoter mutations were detected in 14 pre-clinical cases (sensitivity 46·67%) and none of the controls (specificity 100·00%). At an estimated BC cumulative incidence of 0·09% in the cohort, the positive and negative predictive values were 100·00% and 99·95% respectively. The mutant allelic fractions decreased with the time interval from urine collection until BC diagnosis (p = 0·033) but the mutations were detectable up to 10 years prior to clinical diagnosis.

“Results provide the first evidence from a population-based prospective cohort study of the potential of urinary TERT promoter mutations as promising non-invasive biomarkers for early detection of BC. Further studies should validate this finding and assess their clinical utility in other longitudinal cohorts.”


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