Iranian Researchers Use Copper Nanoparticles to Promote Rapid Wound Healing

Saturday, April 4, 2020 - 16:25

Researchers of Royan Institute and University of Mazandaran have discovered the effect of copper nanoparticles (CuNPs) on wound healing.

According to an ISCA report, Iranian researchers investigated the potential therapeutic effect of various CuNPs concentrations (1 μM, 10 μM, 100 μM, 1 mM, and 10 mM) and sizes (20 nm, 40 nm, 80 nm) in wound healing.

Based on the research, carried out by the researchers including Sanaz Alizadeh, Bagher Seyedalipour, Saeed Shafieyan, Abolfazl Kheime, Parvaneh Mohammadi and Nasser Aghdami, the 10 μM concentration of 40 nm CuNPs and the 1 μM concentration of 80 nm CuNPs were not toxic to the cultured fibroblast, endothelial, and keratinocyte cells, and also 1 μM concentration of 80 nm CuNPs enhanced endothelial cell migration and proliferation.

According to the research, "extensive assessment of in vivo wound healing demonstrated that the 1 μM concentration of 80 nm CuNPs accelerated wound healing over a shorter time via formation of granulation tissue and higher new blood vessels.

"Importantly, serum biochemical analysis confirmed that the 40 nm CuNP (10 μM) and 80 nm CuNP (1 μM) did not show any accumulation in the liver during wound healing. Overall, the results have indicated that the 1 μM concentration of 80 nm CuNPs is a promising NP for wound healing applications without adverse side effects."

The results of the research has been published in the journal of Biochemical and Biophysical Research Communication.

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