Researchers Claim Experimental Gene Therapy Prevents Obesity

Tuesday, May 12, 2020 - 11:44

scientists from Washington University School of Medicine in St. Louis, has found a novel gene therapy can prevent obesity and build muscle without the need for additional exercise, in mice being fed a high-fat diet.

According to the New Atlas report, follistatin, a protein expressed in almost all animal tissue, was first discovered and described in the late 1980s. Initially investigated for its role as a reproductive hormone, follistatin was subsequently found to influence a number of cellular processes, including muscle proliferation.

The research explored whether this kind of therapy could help treat osteoarthritis by increasing muscle mass and reducing metabolic inflammation linked to obesity.

“Obesity is the most common risk factor for osteoarthritis,” explains Farshid Guilak, senior investigator on the new research. “Being overweight can hinder a person’s ability to exercise and benefit fully from physical therapy.”

Guilak describes the subsequent results as “profound,” with the animals building muscle mass without gaining additional weight, despite being fed a high-fat diet and not exercising any more than normal. The gene therapy notably mitigated cartilage degeneration, synovial inflammation, and bone remodeling linked to joint injury and osteoarthritis.

“We’ve identified here a way to use gene therapy to build muscle quickly,” says Guilak. “It had a profound effect in the mice and kept their weight in check, suggesting a similar approach may be effective against arthritis, particularly in cases of morbid obesity.”

This new research suggests follistatin gene therapy generates a number of multifactorial effects, not just influencing muscle mass but also broad metabolic activities that can somehow counter caloric intakes in high fat diets.

Something like this could take years to develop, but we’re excited about its prospects for reducing joint damage related to osteoarthritis, as well as possibly being useful in extreme cases of obesity,” concludes Guilak.

The new research was published in the journal Science Advances.

Source: Washington University School of Medicine in St. Louis

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