Iranian Researchers Can Detect Metastases Early in People with Cancer

Saturday, May 16, 2020 - 10:08

Iranian researchers have succeeded in early detection of metastases in people with cancer.

According to an ISCA report, one of the challenges encountered in microRNA (miRNA) studies is to observe their dual role in different conditions and cells. This leads to a tougher prediction of their behavior as gene expression regulators.

Based on the research which its results have been published in the journal of Cellular Physiology, miR‐203 has been identified to play a negative role in the progression of malignant melanoma; however, it has been reported, with dual effect, as both an oncomiR and tumor suppressor miRNA in some malignancies, such as breast cancer, meanwhile, the role of miR‐203 in melanoma stem cells or even metastatic cells is unclear.

In this study, after observation of upregulation of miR‐203 in melanoma patient's serum and also melanospheres as cancer stem cells model, we examined its overexpression on the stemness potential and migration ability of melanoma cells.

The data demonstrated that the increased miR‐203 level was significantly associated with significant increase in the ability of proliferation, colony and spheres formation, migration, and tumorigenesis in A375 and NA8 cells.

All of these changes were associated with enhancement of BRAF, several epithelial to mesenchymal transition factors, and stemness genes. In conclusion, the results clearly determined that miR‐203 could be down‐regulated in melanoma tissues but be overexpressed in melanoma stem cells. It has an important role as oncomiR and promote repopulation, tumorigenicity, self‐renewal, and migration. Therefore, researchers suggested overexpression of miR‐203 as biomarker for early detection of metastasis. However, more studies are needed to validate our data.

The research was conducted by Parisa Sahranavardfard, Javad Firouzi, Masoumeh Azimi, Pardis Khosravani, Raheleh Heydari, Amirnader Emami Razavi, Mahshad Dorraj, Faezeh Keighobadi and Marzieh Ebrahimi.


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