AUT Scientists Create Antimicrobial, Anti-Cancer Wound Dressing

Sunday, June 21, 2020 - 14:12

A group of scientists from the Faculty of Textile Engineering at Amirkabir University of Technology in collaboration with researchers of University of Granada in Spain have succeeded to make and produce wound dressings with antimicrobial and anti-cancer properties.

According to an ISCA report, Seyed Abbas Nourian Najafabadi, a textile graduate, explained that two types of metal-organic framework called glutamate-zinc framework have been used as BioMOF and metal-organic framework (3.5-dimethyl-4-carboxy pirazolate-zinc as MOF)."

Nourian declared that "By placing the drug in the porous structure of the metal-organic framework, controlled release of the drug is possible and the wound dressing can be used for a longer period of time. In this regard, using nitric acid gas (a gas with antimicrobial properties) and fluorouracil (anti-cancer skin) can be used for wound dressing with antimicrobial or anti-cancer pad properties."

Based on the research, “Risk factors of nonhealing wounds include persistent bacterial infections and rapid onset of dehydration; therefore, wound dressings should be used to accelerate the healing process by helping to disinfect the wound and provide moisture.

“In this research, the Iranian scientists studied the physicochemical properties of the dressing using Fourier transform infrared, 1H NMR, and 13C NMR spectroscopies and scanning electron microscopy, energy-dispersive X-ray, and thermomechanical analyses.

“The surface-modified polyurethane demonstrated improved hydrophilicity and tensile Young’s modulus that approximated natural skin, which was in the range of 1.5–3 MPa. Cell viability and in vitro wound closure, assessed by MTS and the scratch assay, confirmed that the dressing was cytocompatible and possessed fibroblast migratory-promoting activity.

“The surface-modified CPU had up to 100% antibacterial activity against Staphylococcus aureus and Escherichia coli as Gram-positive and Gram-negative bacteria, respectively. In vivo assessments of both noninfected and infected wounds revealed that the surface-modified CPU dressing resulted in a faster healing rate because it reduced the persistent inflammatory phase, enhanced collagen deposition, and improved the formation of mature blood vessels when compared with CPU and commercial Tegaderm wound dressing.”

As Nourian noted, this study has been conducted in collaboration with the University of Granada for two years, led by Hemmatinejad (a faculty member of Amirkabir University of Technology) and Jorge Navarro (a faculty member of the University of Granada-Spain).

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