Researchers Discover Novel Genetic Variants Linked to Type-2 Diabetes

Wednesday, June 24, 2020 - 09:52

Researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration's (VHA) Corporal Michael J. Crescenz Veterans Affairs Medical Center (CMCVAMC) have discovered hundreds of genetic variants never before linked to Type-2 Diabetes.

After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers identified gene variants that vary by ethnicity, as well as variants tied to conditions related to type-2 diabetes like coronary heart disease and chronic kidney disease, Medical Xpress reports.

This expansive genetic investigation, the largest of its kind, has the potential to dramatically impact care for millions of people worldwide who suffer from this disease. The study is published in the latest edition of the journal Nature Genetics.

Using data from the world's biggest biobank—the Million Veteran Program (MVP) in the VHA—plus the DIAGRAM Consortium, the UK Biobank, the Penn Medicine Biobank, and Biobank Japan, the researchers analyzed a study population of 1.4 million people around the world, of which almost 230,000 people had type-2 diabetes.

From there, they broke down the genetic makeup of those hundreds of thousands of people and found 558 independent genetic variants that are differentially distributed between people with and without type-2 diabetes, 21 being European-ancestry-specific and seven African American-ancestry specific.

Of the 588 variants found, 286 had never before been discovered. Researchers then set out to see if certain genetic variants among this group of people could be tied to specific type-2-diabetes-related diseases.

"Ultimately, three were linked to coronary heart disease, two to acute ischemic stroke, four to retinopathy, two to chronic kidney disease, and one to neuropathy," said Marijana Vujkovic, Ph.D., a biostatistician at both the Perelman School of Medicine at the University of Pennsylvania, VHA's CMCVAMC and a co-leader for the VHA's national MVP Cardiometabolic Working Group.

"Building on this research, the scientific community can assess which of the surrounding genes nearby the identified genetic variants is likely to be the causal gene that alters the risk of type-2 diabetes, and that could lead to early interventions to limit controllable risks of developing the condition."

While so many genetic variants were found in people with type-2 diabetes, no one variant was implicated as the "worst" or "most dangerous," said co-senior author Benjamin F. Voight, Ph.D., an associate professor of Systems Pharmacology and Translational Therapeutics at Penn, and a co-leader for the VHA's national MVP Cardiometabolic Working Group.

"However, just like heart disease, schizophrenia, or obesity, it is the accumulation of a large number of these variants that can add up to a considerable increase in risk. We hope this study can not only help find that subset of patients with substantial risk, but also to motivate new, future studies for treatments based on these findings."

Opinions


Popular News

Latest News