Iranian Researchers Present Effective Treatment to Target GBM

Saturday, July 11, 2020 - 10:25
brain cancer

Iranian researchers in cooperation with researchers from Canada, Switzerland and Poland have succeeded to present one of the most promising treatments for Glioblastoma multiforme (GBM) (also called glioblastoma, a fast-growing glioma that develops from star-shaped glial cells (astrocytes and oligodendrocytes) that support the health of the nerve cells within the brain.

According to an ISCA report, Natural Killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology is limited by the availability of sufficient numbers of fully functional cells.

Based on the research which its results are available in International Journal of Molecular Sciences, researchers investigated the efficacy of NK cells that were expanded and treated by interleukin-2 (IL-2) and heat shock protein 70 (HSP70), both in vitro and in vivo.

Proliferation and cytotoxicity assays were used to assess the functionality of NK cells in vitro, after which treated and naïve NK cells were administrated intracranially and systemically to compare the potential antitumor activities in our in vivo rat GBM models.

In vitro assays provided strong evidence of NK cell efficacy against C6 tumor cells. In vivo tracking of NK cells showed efficient homing around and within the tumor site. Furthermore, significant amelioration of the tumor in rats treated with HSP70/Il-2-treated NK cells as compared to those subjected to nontreated NK cells, as confirmed by MRI, proved the efficacy of adoptive NK cell therapy.

Moreover, results obtained with systemic injection confirmed migration of activated NK cells over the blood brain barrier and subsequent targeting of GBM tumor cells. Our data suggest that administration of HSP70/Il-2-treated NK cells may be a promising therapeutic approach to be considered in the treatment of GBM.

The research was done by Farzaneh Sharifzad, Soura Mardpour, Marzieh Ebrahimi, Amir Ali Hamidieh and their colleagues in Royan Institute, Kashan University of Medical Sciences and Health Services, Tehran Imam Khomeini Hospital Complex, Tarbiat Modares University and Tehran University of Medical Sciences.

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