Iranian Researcher Creates Oxygen-Releasing Nanofibers for Breathable Bone Tissue

Monday, July 13, 2020 - 11:31

Researchers at Biomedical Engineering Faculty of Amirkabir University of Technology have developed an oxygen-releasing nanofibrous scaffold by electrospinning of polylactic acid/nano-calcium peroxide suspension with different polylactic acid concentrations.

According to an ISCA report, the research, published in Journal of Biomaterials Applications, shows that an oxygen-releasing nanofibrous scaffold has been developed by electrospinning of polylactic acid/nano-calcium peroxide suspension with different polylactic acid concentrations (6.5 and 13% w/v).

The research executor, Sajedeh Khorshidi explained that oxygen is a vital molecule for cell and tissue processes. Electrospun fibers have been extensively used as drug loading carriers due to possibility of well control over drug release with modulating fiber properties.

Based on the study, however, they have not been used as depots for oxygen release. The electrospun fibers with calcium peroxide cargo provided oxygen content of 30–94 mmHg in a period of 14 days which lies well within the oxygen level of osseous tissue.

“The release profile of 13% polylactic acid fibers was different with that of 6.5% fibers with respects to the initial content of released oxygen and the release rate. Not only did 13% fibers supply oxygen with a slower rate, but also they resulted in a lower burst release of oxygen.

“Cell culture studies in hypoxia corroborated that 13% polylactic acid fibers better preserve cell viability comparing 6.5% counterparts as perceived by MTT assay. Moreover, they endowed more favored milieu for adherence, arrangement and migration of mesenchymal stem cells as confirmed by microscopy images.

“ The oxygen-releasing fibers equally affected alkaline phosphatase, osteocalcin, and calcium deposition by mesenchymal stem cells most likely due to interplay between topographical and metabolic cues offered by 6.5 and 13% formulations.”

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