Iranian Researchers Create Electrochemical ROS Detector in Fresh Sputum for Real-Time Screening of COVID-19

Sunday, July 19, 2020 - 13:28
Electrochemical ROS Detector

A group of Iranian researchers from University of Tehran, Breast Cancer Research Center, Tehran University of Medical Sciences, Shahid Beheshti University of Medical Sciences, Pasteur Institute of Iran and Shiraz University of Medical Sciences have designed a simple electrochemical sensor to selectively detect the intensity of Reactive Oxygen Species (ROS) in the sputum sample.

According to an ISCA report, one of the crucial side effects of COVID viruses in lung host cells is inducing mitochondrial ROS functions to promote viral replications as far it has been reported that cellular reactive oxygen species were markedly increased in SARS-CoV3L pro-expressing cells.

In this study, researchers designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500 μl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.

Based on the research, advanced electronic biosensors could also be helpful in the early-stage screening of COVID-19. Here an electrochemical ROS detector in the sputum sample was applied for real-time screening of people might be suspicious to COVID-19. More than 97% of true positive patients were detected while the sensor declares the diagnosis in less than 30 s.

It can be used as a power full assistant in the fast screening of the patients who need further medical examination during this pandemic and may be used in the future to reduce the number of cases that must be undergone CT-Scan for COVID-19 diagnosis.

The research has been carried out by Zohreh Sadat Miripour, Ramin Sarrami-Forooshani, Hassan Sanati, Jalil Makarem, Morteza Sanei Taheri, Fatemeh Shojaeian, Aida Hasanzadeh Eskafi, Fereshteh Abbasvandi, Naser Namdar, Hadi Ghafari, Parisa Aghaee, Ashkan Zandi, Mahsa Faramarzpour, Meisam Hoseinyazdi, Mahtab Tayebi and Mohammad Abdolahad.

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