AI Model Can Distinguish Different Odor Percepts

Sunday, August 2, 2020 - 13:09
Odor Percepts

A team of artificial intelligence researchers from University of California, Riverside have created an AI model which can distinguish smells from one another based on the chemical makeup of the odor in question.

According to cell and systems biologist at UC Riverside, Anandasankar Ray, the researchers tried to base their AI model on how humans perceive smells. The human nose contains approximately 400 olfactory receptors (ORs) that are activated when chemicals enter the nose. Different ORs are activated by different sets of chemicals and together they are capable of detecting a wide range of different chemical structures and families, Unite.AI reports.

While scientists know a fair amount regarding how ORs detect and interpret the different molecules within an odor, what’s less known is how the stimulus that the ORs detect translates to a sensory experience, or percept, the experience of smelling something.

As Phy.org reported, Ray explained that researchers attempted to model human olfactory percepts through a combination of machine learning algorithms and chemical informatics. Machine learning algorithms are capable of analyzing the large number of chemical variables, pulling their common structures and patterns out, and then learning to identify which chemicals will have certain smells. After being trained, the algorithms can eventually predict how novel chemical combinations will smell even if the data is unlabeled and it’s unknown how the chemical smells.

The research team started by creating methods that would allow a computer to determine which chemical features were capable of activating ORs. Afterwards, the researchers analyzed over half a million chemical compounds to find samples that were capable of binding to 34 ORs. The researchers then tried to estimate the perceptual qualities of the chemical samples with the same algorithm used to predict OR activity.

The research team found that combinations of different OR activations seemed to have a relationship with perceptual coding. The researchers utilized data that contained evaluations of chemicals by human volunteers and selected the ORs that delivered the best precept predictions on a subset of the chemical samples. They then tested whether or not the OR activations were predictive of new scents.

According to the researchers, the OR activity could be used to correctly predict the percepts of 146 different chemicals. Only a few of the ORs were required to predict the percepts, not all of the ORs. The researchers confirmed this hypothesis on fruit flies and managed to successfully predict an aversion or attraction to different scents.

Ray explained that the advantage of digitizing smells and the predictions associated with them is that the results can be used to determine new kinds of chemicals that can be used in the creation of new kinds of fragrances and foods. The AI could be used to find replacements that smell similar to chemicals that are becoming expensive or rare. It could also be used to replace unpleasant smelling compounds with chemicals that are more appealing to humans.

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