Iranian Researchers Present Diet-Based Recommendations Prevents Non-Alcoholic Fatty Liver Disease

Saturday, September 12, 2020 - 12:17
Fatty Liver

Ahvaz Jundishapur University of Medical Sciences researchers have identified major dietary patterns and their association with the risk of non-alcoholic fatty liver disease (NAFLD).


According to an ISCA report, Narges Dehghanseresht, Sima Jafarirad, Seyed Pejman Alavinejad and Anahita Mansoori carried out the research which aims at identifying major dietary patterns and their association with the risk of NAFLD.

Based on the research, which its results published in Nutrition Journal, a total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. The patients with NAFLD were diagnosed by a gastroenterologist. The participants’ dietary intake data were collected using a 147-item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. Adherence to dietary patterns was divided into tertiles and its association with odds of NAFLD was investigated by multivariate logistic regression.

The results showed four major dietary patterns, among which adherence to the “ordinary pattern” was positively associated with NAFLD risk. After adjusting for all confounding factors, individuals in the highest tertile of “ordinary pattern” exhibited a significantly elevated risk of NAFLD compared to the lowest tertile (OR = 3.74, 95%CI = 1.23–11.42, P trend< 0.001).

As well as, Individuals in the second and third tertiles of the “traditional pattern” were associated with the risk of NAFLD compared to the lowest tertile (medium vs. lowest tertile OR = 2.37, 95%CI = 1.02–5.53; highest vs. lowest tertile OR = 3.58, 95% CI = 1.48–8.68, P trend< 0.001). The highest tertile of “vegetable and dairy pattern” compared to the lowest tertile was inversely associated with NAFLD risk (OR = 0.23, 95%CI = 0.09–0.58, P trend = 0.02). No significant association was found between “fast food type pattern” and the risk of NAFLD.

A significant association was observed between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for preventing NAFLD in individuals who are at a high risk for progression of NAFLD.

The results display that high adherence to the “ordinary” and “traditional” dietary patterns increase the risk of NAFLD, while adherence to a “vegetable and dairy” pattern has a negative association with NAFLD in Ahvaz population. The findings can be served as a dietary strategy for preventing and treating NAFLD. Nevertheless, more studies are required to confirm our results.



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